Noto anche come
Tripsina e chimotripsina
Nome ufficiale
Tripsina e chimotripsina fecale
Ultima Revisione:
Ultima Modifica:
15.01.2018.
In Sintesi
Perché fare il test?

Per la rilevazione della fibrosi cistica (nei neonati e nei bambini); talvolta per rilevare e valutare un’insufficienza pancreatica (nei bambini e negli adulti).

Quando fare il test?

Nel caso in cui un bambino o un neonato abbia i sintomi di fibrosi cistica come diarrea persistente, produzione di feci maleodoranti, grasse e voluminose, malnutrizione e carenza vitaminica; nel caso in cui in un bambino o in un adulto vi sia il sospetto di un’insufficienza pancreatica.

Che tipo di campione viene richiesto?

Un campione di feci fresco e non contaminato con le urine.

 

Il test richiede una preparazione?

No, nessuna.

L'Esame

La tripsina e la chimotripsina sono enzimi responsabili della digestione delle proteine nell’intestino tenue. I loro precursori inattivi, il tripsinogeno e il chimostripsinogeno, sono prodotti nel pancreas e trasportati nell’intestino tenue. Qui il tripsinogeno viene attivato a tripsina la quale, a sua volta, converte il chimotripsinogeno a chimotripsina. Insieme questi due enzimi sono responsabili della degradazione delle proteine assunte con la dieta, in piccoli peptidi. Sia la tripsina che la chimotripsina sono rilevabili nelle feci, se il pancreas funziona normalmente. Il test rileva la tripsina e la chimotripsina presenti nelle feci al fine di valutare la funzionalità pancreatica.


Nelle persone affette da fibrosi cistica possono formarsi tappi di muco al livello dei dotti pancreatici in grado di bloccare il passaggio del tripsinogeno e del chimotripsinogeno all’intestino tenue.


Le persone affette da disfunzioni pancreatiche (danneggiamento tissutale o ostruzione) possono anche andare incontro a blocco dei dotti pancreatici o a distruzione delle cellule producenti tripsinogeno e chimoptripsinogeno. Questo tipo di danno può comportare l’insorgenza di insufficienza pancreatica con la conseguente diminuzione della quantità di enzimi pancreatici trasportati nell’intestino tenue e quindi l’inadeguata digestione degli alimenti. Questa condizione può essere una conseguenza di pancreatiti croniche o tumori pancreatici.

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Fonti

NOTA: Questa sezione è basata sulla ricerca che utilizza le fonti qui citate insieme all’esperienza collettiva della Revisione Editoriale di Lab Tests Online. Questa sezione  è periodicamente rivista dalla Revisione Editoriale e può essere aggiornata come risultato della revisione. Ogni nuova fonte citata sarà aggiunta alla lista e distinta dalle fonti originali.  

 

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